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Sunday, May 10, 2020 | History

2 edition of Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents (Enzyme Inhibitors) found in the catalog.

Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents (Enzyme Inhibitors)

Paul J. Smith

Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents (Enzyme Inhibitors)

by Paul J. Smith

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Published by CRC Press .
Written in English

    Subjects:
  • Oncology,
  • Medical / Nursing

  • The Physical Object
    FormatHardcover
    Number of Pages448
    ID Numbers
    Open LibraryOL9596758M
    ISBN 101420005405
    ISBN 109781420005400

    Cyclin-dependent kinases (CDKs) are members of subfamily of serine/threonine kinases which are found in both unicellular organisms such as yeast and multicellular organisms such as plants, humans and other mammals [1,2,3,4,5].These kinases are dependent on cyclin-binding activity for their activation, thereby resulting in specific complex by:   Providing the most up-to-date, in-depth coverage available in a single volume, Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents surveys the success of the agents developed thus far, the possibility of new routes to more selective inhibitors, and the growing appreciation of critical, therapeutic : Charles M. Hansen.

    At the same time, inhibitors of the cyclin-dependent kinases (CDK) 4/6 will delay and reverse endocrine resistance with tolerable adverse effects [1, 2]. It is well acknowledged that CDK4/6 inhibitors mainly block retinoblastoma tumor suppressor protein phosphorylation, . Lamellarins, a family of hexacyclic pyrrole alkaloids originally isolated from marine invertebrates, display promising anti-tumor activity. They induce apoptotic cell death through multi-target mechanisms, including inhibition of topoisomerase I, interaction with DNA and direct effects on mitochondria. We here report that lamellarins inhibit several protein kinases relevant to cancer such as Cited by:

    D-type cyclins (D1, D2 and D3) together with their associated cyclin-dependent kinases CDK4 and CDK6 are components of the core cell cycle machinery that drives cell proliferation. Inhibitors of CDK4 and CDK6 are currently in clinical trials for patients with several cancer types, with promising results.   Addition of CDK4/6 inhibitors (CDK4/6i) to endocrine therapy significantly increased progression-free survival, leading to their approval and incorporation into the metastatic breast cancer treatment paradigm. With these inhibitors being routinely used for patients with advanced estrogen receptor-positive (ER+) breast cancer, resistance to these agents and its impact on subsequent Author: Hitisha K. Patel, Nianjun Tao, Kyung-Min Lee, Mariela Huerta, Heike Arlt, Tara Mullarkey, Steven Tro.


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Inhibitors of Cyclin-Dependent Kinases as Anti-Tumor Agents (Enzyme Inhibitors) by Paul J. Smith Download PDF EPUB FB2

Book Description. One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation.

With contributions from the top international researchers in the field. Summary One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation.

With contributions from the top international researchers in the field, the. One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation.

With contributions from the top international researchers in the field, the book takes a 5/5(1). One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation.

With contributions from the top international researchers in the field, the book takes a. One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for pharmacological modulation.

With contributions from the top inteCited by: INTEGRATION OF CELL CYCLE CONTROL PATHWAYS AND THE OPPORTUNITIES FOR TARGETING Cell Cycle Dynamics and the Challenges for CDK Targeting Paul J.

Smith, Emeline Furon, and Rachel J. Errington Functional Regulation of CIP/KIP CDK Inhibitors Mong-Hong Lee and Ruiying Zhao Mouse Models to Study the In Vivo Function of Cyclin-Dependent Kinases in.

Part Section 1: Integration of Cell Cycle Control Pathways and the Oppertunities for Targeting --chapter 1 Cell Cycle Dynamics and the Challenges for CDK Targeting --chapter 2 Functional Regulation of CIP/KIP CDK Inhibitors --chapter 3 Mouse Models to Study the In Vivo Fuction of Cyclin-Dependent Kinases in Normal Homeostasis and Tumor.

As a cytostatic mechanism, however, Flavopiridol strongly inhibits the cyclin-dependent kinases (cdk1, cdk2, cdk4, cdk7), with the potential to cause inhibition of cell cycle progression in G(1. CDK4 and 6 Inhibitors as Sensitizing Agents for Cancer Chemotherapy Based on the binding interactions, the protein kinase inhibitors are classified into types I and II [25], [36].

Type-I inhibitors are ATP-competitive inhibitors that function by interacting with the ATP Author: Qingbin Cui, Qingbin Cui, Pranav Gupta, Lei Zhang, Lei Zhang, Zhe-Sheng Chen. Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents 1st Edition.

Paul J. Smith, Eddy W. Yue Octo One of the few books to cover all aspects of cyclin-dependent kinases (CDKs), Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents provides an overview of CDKs as molecular and functional entities, their involvement in different disease processes, and their potential for.

We use cookies to offer you a better experience, personalize content, tailor advertising, provide social media features, and better understand the use of our services. READ THE NEW BOOK Angiotensin-Converting Enzyme Inhibitors: Scientific Basis for Clinical Use BOOK.

Lufyimik. [Download] Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents (Enzyme Inhibitors Series) Leneciagray. From antibiotics to statins, modern medicine relies on the reliability and ease-of-use of enzyme- and receptor-directed inhibitors and Inhibitor Index is a comprehensive, curated compendium of over 7, enzyme inhibitors and receptor antagonists, including many toxins, poisons, and metabolic uncouplers.

Author(s): Smith,Paul J(Paul James),; Yue,Eddy W Title(s): Inhibitors of cyclin-dependent kinases as anti-tumor agents/ edited by Paul J. Smith, Eddy W. Yue. Country of Publication: United States Publisher: Boca Raton: CRC/Taylor & Francis, c Pyrazolopyridazine 1a was identified in a high-throughput screening carried out by BASF Bioresearch Corp.

(Worcester, MA) as a potent inhibitor of CDK1/cyclin B and shown to have selectivity for the CDK family.

Analogues of the lead compound have been synthesized and their antitumor activities have been tested. A molecular model of the complex between the lead compound and the CDK2 ATP binding. Pyrazoles as efficient adenine-mimetic heterocycles for the discovery CDK inhibitors Pevarello P, Vulpetti A Inhibitors of cyclin-dependent kinases as anti-tumor agents (Book) () 15, Abstract.

Protein kinase inhibitors are the front runners in signal transduction therapy, because the catalytic sites of enzymes are easier targets for drug design than protein–protein interaction domains. It has been recognized that protein tyrosine kinases comprise a major fraction of the signaling elements on whose activities the survival of the Cited by: Inhibitors of cyclin-dependent kinases as anti-tumor agents (Book) () 15, Cell-cycle inhibitor profiling by high-content analysis Gasparri F, Ciavolella A, Galvani A Advances in Molecular Oncology (Book) ()Cross platform microarray analysis for robust identification of differentially expressed genes.

The abundance of biochemical and structural knowledge on the Cyclin-Dependent Kinases Part of the Methods in Molecular Biology book series (MIMB, volume McInnes C () Progress in the evaluation of CDK inhibitors as anti-tumor : Asterios I. Grigoroudis, George Kontopidis. Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents (Crc Enzyme Inhibitors) by Paul J.

Smith(Editor) Eddy W. Yue(Editor) Hardcover | CRC | Pub. Date: ISBN: | ISBN. Meijer L () Cyclin-dependent kinases inhibitors as potential anticancer, anti-neurodegenerative, antiviral and antiparasitic agents. Drug Resist Updat 3: 83–88 PubMed Google Scholar Cited by: Book Chapter.

CDK inhibitors as anti-cancer agents: Perspectives for the future. Authors: Jayalakshmi Sridhar, Nagarajan Pattabiraman, Eliot M. Rosen, Richard G. Pestell. Inhibitors of Cyclin-dependent Kinases as Anti-tumor Agents, Edited by Paul James Smith. robot-based discovery of protein kinase inhibitors as novel anti-tumor agents c.

schächtele, f. totzke and d. marmé - p a phase i trial of the cyclin dependent kinase inhibitor flavopiridol in patients with refractory neoplasms.